5  structures 882  species 1128  sequences

Family: RNase_MRP (RF00030)

Description: RNase MRP



This family is a member of clan (CL00002), which contains the following 7 members:

RNaseP-T RNaseP_arch RNaseP_bact_a RNaseP_bact_b RNaseP_nuc RNase_MRP RNase_P

Wikipedia annotation Edit Wikipedia article

The Rfam group coordinates the annotation of Rfam families in Wikipedia. This family is described by a Wikipedia entry RNase MRP. More...

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.



There are various ways to view or download the seed alignments that we store. You can use a sequence viewer to look at them, or you can look at a plain text version of the sequence in a variety of different formats. More...

View options

You can view Rfam seed alignments in your browser in various ways. Choose the viewer that you want to use and click the "View" button to show the alignment in a pop-up window.


Formatting options

You can view or download Rfam seed alignments in several formats. Check either the "download" button, to save the formatted alignment, or "view", to see it in your browser window, and click "Generate".

Alignment format:


Download a gzip-compressed, Stockholm-format file containing the seed alignment for this family. You may find RALEE useful when viewing sequence alignments.

Submit a new alignment

We're happy receive updated seed alignments for new or existing families. Submit your new alignment and we'll take a look.

Secondary structure

This section shows a variety of different secondary structure representations for this family. More...

You can view the secondary structure of the family using the VARNA applet. You can see more information about VARNA iself here.

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Tree controls


The tree shows the occurrence of this RNA across different species. More...


Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.


This page displays the predicted phylogenetic tree for the alignment. More...

This tree was built using the fasttree method.

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Note: You can also download the data file for the seed tree.


For those sequences which have a structure in the Protein DataBank, we generate a mapping between EMBL, PDB and Rfam coordinate systems. The table below shows the structures on which the RNase_MRP family has been found.

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Motif matches

There are 4 motifs which match this family.

This section shows the Rfam motifs that match sequences within the seed alignment of this family. Users should be aware that the motifs are structural constructs and do not necessarily conform to taxonomic boundaries in the way that Rfam families do. More...

Original order Motif Accession Motif Description Number of Hits Fraction of Hits Sum of Bits Image
7 RM00005 CsrA/RsmA binding motif 10 0.152 73.7 Match Image
7 RM00008 GNRA tetraloop 33 0.500 351.5 Match Image
7 RM00024 T-loop 7 0.106 73.6 Match Image
7 RM00029 UNCG tetraloop 10 0.152 140.0 Match Image


This section shows the database cross-references that we have for this Rfam family.

Literature references

  1. Schmitt ME, Bennett JL, Dairaghi DJ, Clayton DA FASEB J 1993;7:208-213. Secondary structure of RNase MRP RNA as predicted by phylogenetic comparison. PUBMED:7678563

  2. Li X, Frank DN, Pace N, Zengel JM, Lindahl L RNA 2002;8:740-751. Phylogenetic analysis of the structure of RNase MRP RNA in yeasts. PUBMED:12088147

  3. Piccinelli P, Rosenblad MA, Samuelsson T Nucleic Acids Res. 2005;33:4485-4495. Identification and analysis of ribonuclease P and MRP RNA in a broad range of eukaryotes. PUBMED:16087735

  4. Walker SC, Avis JM Biochem Biophys Res Commun. 2005;335:314-321. Secondary structure probing of the human RNase MRP RNA reveals the potential for MRP RNA subsets. PUBMED:16083861

  5. Rosenblad MA, Lopez MD, Piccinelli P, Samuelsson T Nucleic Acids Res. 2006;34:5145-5156. Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. PUBMED:16998185

External database links

Curation and family details

This section shows the detailed information about the Rfam family. We're happy to receive updated or improved alignments for new or existing families. Submit your new alignment and we'll take a look.


Seed source Published; PMID:12088147, Griffiths-Jones SR, Daub J
Structure source Published; PMID:7678563
Type Gene; ribozyme;
Author Griffiths-Jones SRORCID logo
Alignment details
Alignment Number of
full 1,062
seed 66

Model information

Build commands
cmbuild -F CM SEED
cmcalibrate --mpi CM
Search command
cmsearch --cpu 4 --verbose --nohmmonly -E 1000 -Z 549862.597050 CM SEQDB
Gathering cutoff 50.0
Trusted cutoff 50.0
Noise cutoff 49.9
Covariance model Download