4  structures 763  species 1353  sequences

Family: RNaseP_nuc (RF00009)

Description: Nuclear RNase P



This family is a member of clan (CL00002), which contains the following 7 members:

RNaseP-T RNaseP_arch RNaseP_bact_a RNaseP_bact_b RNaseP_nuc RNase_MRP RNase_P

Wikipedia annotation Edit Wikipedia article

The Rfam group coordinates the annotation of Rfam families in Wikipedia. This family is described by a Wikipedia entry Nuclear RNase P. More...

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.



There are various ways to view or download the seed alignments that we store. You can use a sequence viewer to look at them, or you can look at a plain text version of the sequence in a variety of different formats. More...

View options

You can view Rfam seed alignments in your browser in various ways. Choose the viewer that you want to use and click the "View" button to show the alignment in a pop-up window.


Formatting options

You can view or download Rfam seed alignments in several formats. Check either the "download" button, to save the formatted alignment, or "view", to see it in your browser window, and click "Generate".

Alignment format:


Download a gzip-compressed, Stockholm-format file containing the seed alignment for this family. You may find RALEE useful when viewing sequence alignments.

Submit a new alignment

We're happy receive updated seed alignments for new or existing families. Submit your new alignment and we'll take a look.

Secondary structure

This section shows a variety of different secondary structure representations for this family. More...

You can view the secondary structure of the family using the VARNA applet. You can see more information about VARNA iself here.

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Tree controls


The tree shows the occurrence of this RNA across different species. More...


Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.


This page displays the predicted phylogenetic tree for the alignment. More...

This tree was built using the fasttree method.

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Note: You can also download the data file for the seed tree.


For those sequences which have a structure in the Protein DataBank, we generate a mapping between EMBL, PDB and Rfam coordinate systems. The table below shows the structures on which the RNaseP_nuc family has been found.

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Motif matches

There are 6 motifs which match this family.

This section shows the Rfam motifs that match sequences within the seed alignment of this family. Users should be aware that the motifs are structural constructs and do not necessarily conform to taxonomic boundaries in the way that Rfam families do. More...

Original order Motif Accession Motif Description Number of Hits Fraction of Hits Sum of Bits Image
7 RM00005 CsrA/RsmA binding motif 23 0.198 194.0 Match Image
7 RM00008 GNRA tetraloop 49 0.422 580.3 Match Image
7 RM00010 Kink turn 1, 3' bulge 23 0.198 242.4 Match Image
7 RM00024 T-loop 15 0.129 170.9 Match Image
7 RM00029 UNCG tetraloop 31 0.267 397.0 Match Image
7 RM00030 U-turn motif 30 0.259 386.0 Match Image


This section shows the database cross-references that we have for this Rfam family.

Literature references

  1. Frank DN, Pace NR Annu Rev Biochem 1998;67:153-180. Ribonuclease P: unity and diversity in a tRNA processing ribozyme. PUBMED:9759486

  2. Brown JW Nucleic Acids Res 1999;27:314. The Ribonuclease P Database. PUBMED:9847214

  3. Frank DN, Adamidi C, Ehringer MA, Pitulle C, Pace NR RNA 2000;6:1895-1904. Phylogenetic-comparative analysis of the eukaryal ribonuclease P RNA. PUBMED:11142387

  4. Xiao S, Scott F, Fierke CA, Engelke DR Annu Rev Biochem 2002;71:165-189. Eukaryotic Ribonuclease P: A Plurality of Ribonucleoprotein Enzymes. PUBMED:12045094

  5. Marquez SM, Harris JK, Kelley ST, Brown JW, Dawson SC, Roberts EC, Pace NR RNA. 2005;11:739-751. Structural implications of novel diversity in eucaryal RNase P RNA. PUBMED:15811915

External database links

Curation and family details

This section shows the detailed information about the Rfam family. We're happy to receive updated or improved alignments for new or existing families. Submit your new alignment and we'll take a look.


Seed source Brown JW, The Ribonuclease P Database, PMID:9847214
Structure source Published; PMID:9847214
Type Gene; ribozyme;
Author Griffiths-Jones SRORCID logo, Mifsud WORCID logo
Alignment details
Alignment Number of
full 1,237
seed 116

Model information

Build commands
cmbuild -F CM SEED
cmcalibrate --mpi CM
Search command
cmsearch --cpu 4 --verbose --nohmmonly -T 16.14 -Z 549862.597050 CM SEQDB
Gathering cutoff 28.0
Trusted cutoff 28.0
Noise cutoff 27.9
Covariance model Download