microRNA Families
A collaboration between Rfam and miRBase to build a fully synchronised, high-quality collection of microRNA families.
- Goal
- Create and review up to 2,000 microRNA families to synchronise Rfam and miRBase, replacing the sequence-only BLAST-based miRBase families with structure-validated Rfam entries and resolving families unique to each database.
- Status
- Phase 2 ongoing.
- Collaborators
- miRBase, Prof Sam Griffiths-Jones, The University of Manchester
Background
miRBase is a database of published miRNA sequences and annotations that provides a centralised system for assigning names to miRNA genes, and is an Expert Database in RNAcentral.
Both Rfam and miRBase classify microRNA families, but prior to Rfam 14.3 the two resources were not coordinated. miRBase used a semi-automated BLAST-based clustering method, giving higher coverage but lower structural quality than Rfam's covariance model approach. At the start of the project, Rfam contained 529 microRNA families while miRBase annotated 1,983 families — with only 28% overlap between them.
Phase 1
As of release 14.10 — 1,536 families created or updated across the project, including 62 new and 138 updated families in the final release.
Phase 2
This phase will focus on updating and improving miRBase families and reflecting those changes in both databases, synchronising miRNAs between Rfam and miRBase releases.
Contact Rfam if you have questions or feedback about this project.
10 Newest miRNA Families
The most recently added miRNA families in Rfam, ordered by creation date.
| Accession ↕ | Rfam ID ↕ | Description | Sequences ↕ | Species ↕ | Created ↕ |
|---|---|---|---|---|---|
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10 Most Recently Updated miRNA Families
The most recently updated miRNA families in Rfam.
| Accession ↕ | Rfam ID ↕ | Description | Sequences ↕ | Species ↕ | Updated ↕ |
|---|---|---|---|---|---|
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