This family is a member of clan (CL00004), which contains the following 4 members:Sacc_telomerase Telomerase-cil Telomerase-vert Telomerase_Asco
Wikipedia annotation Edit Wikipedia article
There are various ways to view or download the seed alignments that we store. You can use a sequence viewer to look at them, or you can look at a plain text version of the sequence in a variety of different formats. More...
You can view Rfam seed alignments in your browser in various ways. Choose the viewer that you want to use and click the "View" button to show the alignment in a pop-up window.
You can view or download Rfam seed alignments in several formats. Check either the "download" button, to save the formatted alignment, or "view", to see it in your browser window, and click "Generate".
Submit a new alignment
We're happy receive updated seed alignments for new or existing families. Submit your new alignment and we'll take a look.
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the More....
The tree shows the occurrence of this RNA across different species. More...
Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.
This page displays the predicted phylogenetic tree for the alignment. More...
Note: You can also download the data file for the seed tree.
There are 1 motifs which match this family.
This section shows the Rfam motifs that match sequences within the seed alignment of this family. Users should be aware that the motifs are structural constructs and do not necessarily conform to taxonomic boundaries in the way that Rfam families do. More...
|Number of Hits
|Fraction of Hits
|Sum of Bits
|HuR binding site
This section shows the database cross-references that we have for this Rfam family.
McCormick-Graham M, Romero DP Nucleic Acids Res 1995;23:1091-1097. Ciliate telomerase RNA structural features. PUBMED:7739888
Lingner J, Hendrick LL, Cech TR Genes Dev 1994;8:1984-1998. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. PUBMED:7958872
Jiang J, Wang Y, Susac L, Chan H, Basu R, Zhou ZH, Feigon J Cell. 2018;173:1179-1190. Structure of Telomerase with Telomeric DNA. PUBMED:29775593
He Y, Wang Y, Liu B, Helmling C, Susac L, Cheng R, Zhou ZH, Feigon J Nature. 2021;593:454-459. Structures of telomerase at several steps of telomere repeat synthesis. PUBMED:33981033
External database links
|GO:0007004 (telomere maintenance via telomerase); GO:0003720 (telomerase activity); GO:0000333 (telomerase catalytic core complex);
Curation and family details
This section shows the detailed information about the Rfam family. We're happy to receive updated or improved alignments for new or existing families. Submit your new alignment and we'll take a look.
|McCormick-Graham and Romero, PMID:7739888; Griffiths-Jones SR, Moxon SJ
|Published; PMID:7958872; PMID:7739888, Moxon SJ
|Griffiths-Jones SR, Moxon SJ, Ontiveros-Palacios N
cmbuild -F CM SEED
cmcalibrate --mpi CM
cmsearch --cpu 4 --verbose --nohmmonly -T 30.00 -Z 742849.287494 CM SEQDB