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Clan: twister_ribozyme (CL00120)


twister ribozyme

Twister ribozyme (Type-P1) RF03160 and variants (Type-P3 and Type-P5) RF03154 and RF02684 have been reported in eukaryotic and bacterial genomes. They are comparable in size and structural complexity to riboswitches and their genetic contexts often bear marked similarities to those of hammerhead ribozymes [1]

This clan contains 3 families and the total number of sequence regions in the clan is 1,122.

Literature references

  1. Roth A, Weinberg Z, Chen AG, Kim PB, Ames TD, Breaker RR, Nat Chem Biol. 2014;10:56-60.: A widespread self-cleaving ribozyme class is revealed by bioinformatics. 24240507


This clan contains the following 3 member families:

Twister-P5 twister-P3 twister-P1

Secondary structures

This tool allows you to view the secondary structure images of two clan members side-by-side. Choose the family structures using the two drop-down menus below.


The table below shows the number of occurrences of each family throughout the sequence database. In brackets beside each number is the percentage of the total number of sequence hits for the clan that are represented by this family. The rightmost column provides a link to the alignments tab for each family.

Rfam family Num. regions Alignment
twister-P1 (RF03160) 1,108 (98.8%) View
twister-P3 (RF03154) 0 (0.0%) View
Twister-P5 (RF02684) 14 (1.2%) View