Rfam: Home page

Rfam 14.4 (December 2020, 3941 families)

The Rfam database is a collection of RNA families, each represented by multiple sequence alignments, consensus secondary structures and covariance models

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Sequence search

Annotate your sequences with RNA families and visualise their secondary structure using R2DT

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Download covariance models, FASTA sequences, database dumps, previous releases, and more

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Help

Access Rfam using the API and public MySQL database, or learn how to annotate genomes using Infernal

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Announcements

Citing Rfam

If you use Rfam, please cite our latest papers:

Rfam 14: expanded coverage of metagenomic, viral and microRNA families
Kalvari et al., Nucleic Acids Research (2020)

Non-coding RNA analysis using the Rfam database.
Kalvari et al., Current Protocols in Bioinformatics (2018)

View all Rfam papers

Current projects

Featured families

SAM riboswitch

The SAM riboswitch seed alignment has been revised using the 3D structure information View family →

manA RNA

The manA seed alignment has been revised using the original ZWD alignment View family →

L4-Archaeoglobi

L4-Archaeoglobi is one of the new r-leader families imported from ZWD View family →

General Flavivirus xrRNA

General Flavivirus exoribonuclease-resistant RNA element is one of the new Flavivirus RNA families View family →

LOOT RNA

LOOT RNA has been imported from ZWD View family →

Alphacoronavirus 5' UTR

Alphacoronavirus 5' UTR includes SL1, SL2, SL4, and SL5 stem loops View family →