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Rfam 14.1 (January 2019,
3016 families)
The Rfam database is a collection of RNA families, each represented by multiple
sequence alignments,consensus secondary structures and covariance
models (CMs).
More...
The families in Rfam break down into three broad functional
classes: non-coding RNA genes, structured cis-regulatory
elements and self-splicing RNAs. Typically these functional
RNAs often have a conserved secondary structure which may be
better preserved than the RNA sequence. The CMs used to
describe each family are a slightly more complicated relative
of the profile hidden Markov models (HMMs) used by Pfam. CMs
can simultaneously model RNA sequence and the structure in an
elegant and accurate fashion.
Rfam families are frequently built from external sources, we ask
that if you find a particular family useful for your work that
you cite both Rfam and the primary source of our data.
If you see anything wrong with any of our alignments or
structures or there is a family that you know of missing from
Rfam please
contact us
with a suggested correction. If you see anything incorrect or omitted
from the Wikipedia
entries we display and link to then be brave and edit the entry; you
might also consider joining the
WikiProject RNA.
Non-coding RNA analysis using the Rfam database.
Ioanna Kalvari, Eric P. Nawrocki, Joanna Argasinska, Natalia Quinones-Olvera, Robert D. Finn, Alex Bateman and Anton I. Petrov
Current Protocols in Bioinformatics (2018)
10.1002/cpbi.51