8  structures 0  species 0  sequences

Motif: CUYG (RM00006)

Description: CUYG tetraloop


Wikipedia annotation Edit Wikipedia article

The Rfam group coordinates the annotation of Rfam data in Wikipedia. This motif is described by a Wikipedia entry entitled Tetraloop. More...

This page is based on a wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.


You can either download the motif alignment or view it directly in your browser window. More...

Formatting options

You can view or download motif alignments in several formats. Check either the "download" button, to save the formatted alignment, or "view", to see it in your browser window, and click "Generate".

Alignment format:


There are 8 PDB entires which have been used to build the motif model.

The table of results below may be sorted by clicking on the column titles, or restored to the original order here.

Original order PDB ID PDB chain ID PDB Residues
2 1J5E A 170 - 207
2 2QAL A 66 - 100
2 2ZJR X 1544 - 1558
2 3zvo A 171 - 207
2 1voz A 57 - 100
2 1j5a A 245 - 271
2 3iz9 A 580 - 610
2 2f1q A 17 - 41

Family matches

There is 1 Rfam family which matches this motif.

This section shows the families which have been annotated with this motif. Users should be aware that the motifs are structural constructs and do not necessarily conform to taxonomic boundaries in the way that Rfam families do. More...

Original order Family Accession Family Description Number of Hits Fraction of Hits Sum of Bits Image
3 RF01772 Pseudomonas rnk leader 3 0.200 57.9 Match Image


This section shows the database cross-references that we have for this Rfam motif.

Literature references

  1. Woese CR, Winker S, Gutell RR Proc Natl Acad Sci U S A. 1990;87:8467-71. Architecture of ribosomal RNA: constraints on the sequence of "tetra-loops". PUBMED:2236056

  2. Wolters J Nucleic Acids Res. 1992;20:1843-50. The nature of preferred hairpin structures in 16S-like rRNA variable regions. PUBMED:1374559

  3. Jucker FM, Pardi A Biochemistry. 1995;34:14416-27. Solution structure of the CUUG hairpin loop: a novel RNA tetraloop motif. PUBMED:7578046

  4. Antao VP, Lai SY, Tinoco I Nucleic Acids Res. 1991;19:5901-5. A thermodynamic study of unusually stable RNA and DNA hairpins. PUBMED:1719483

External database links

Curation and motif details

This section shows the detailed information about the Rfam motif. We're happy to receive updated or improved alignments for new or existing families. Submit your new alignment and we'll take a look.


Seed source Published; PMID:7578046
Structure source N/A
Type Stem Loop
Author Gardner PP
Alignment details
Alignment Number of
Average length Sequence
identity (%)
seed 8 31.25 40

Model information

Build commands
cmbuild -F CM SEED
cmcalibrate --mpi --seed 1 CM
Gathering cutoff 19.0
Covariance model Download the Infernal CM for the motif here