Glycine riboswitch clan

Glycine riboswitches clan include the glycine riboswitch first reported in [1] and the glycine-GGAnGA variant which is particular in genes that encode either saccharopine dehydrogenase or amino acid transporters and other genes with not predicted function [2].

This clan contains 2 families and the total number of sequence regions in the clan is 9,461.

Literature references

1. Mandal M, Lee M, Barrick JE, Weinberg Z, Emilsson GM, Ruzzo WL, Breaker RR, Science 2004;306:275-279.: A glycine-dependent riboswitch that uses cooperative binding to control gene expression. 15472076
2. Weinberg Z, Nelson JW, Lunse CE, Sherlock ME, Breaker RR, Proc Natl Acad Sci U S A. 2017;114:E2077.: Bioinformatic analysis of riboswitch structures uncovers variant classes with altered ligand specificity. 28265071

Members

This clan contains the following 2 member families:

Glycine glycine-GGAnGA

For those sequences which have a structure in the Protein DataBank, we generate a mapping between EMBL, PDB and Rfam coordinate systems. The table below shows the mapping between the Rfam families in this clan, the corresponding EMBL entries, and the region of the three-dimensional structures that are available for that sequence.

This tool allows you to view the secondary structure images of two clan members side-by-side. Choose the family structures using the two drop-down menus below.

The table below shows the number of occurrences of each family throughout the sequence database. In brackets beside each number is the percentage of the total number of sequence hits for the clan that are represented by this family. The rightmost column provides a link to the alignments tab for each family.

Rfam family	Num. regions	Alignment
glycine-GGAnGA (RF03166)	36 (0.4%)	View
Glycine (RF00504)	9,425 (99.6%)	View