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Clan: S4_rleader (CL00119)


Ribosomal Protein S4 Leader clan

The S4 rleaders are motifs that likely bind the S4 r-protein, they have potential to imitate the rRNAs binding site (GUAA sequence). rleaders has been propose participate in an autoregulatory mechanism to control the concentration of the ribosomal proteins [1]

This clan contains 4 families and the total number of sequence regions in the clan is 296.

Literature references

  1. Eckert I, Weinberg Z, BMC Microbiol. 2020;20:130.: Discovery of 20 novel ribosomal leader candidates in bacteria and archaea. 32448158


This clan contains the following 4 member families:

S4-Fusobacteriales S4-Bacteroidia S4-Clostridia S4-Flavobacteria

Secondary structures

This tool allows you to view the secondary structure images of two clan members side-by-side. Choose the family structures using the two drop-down menus below.


The table below shows the number of occurrences of each family throughout the sequence database. In brackets beside each number is the percentage of the total number of sequence hits for the clan that are represented by this family. The rightmost column provides a link to the alignments tab for each family.

Rfam family Num. regions Alignment
S4-Flavobacteria (RF03141) 176 (59.5%) View
S4-Clostridia (RF03140) 39 (13.2%) View
S4-Bacteroidia (RF03139) 63 (21.3%) View
S4-Fusobacteriales (RF03133) 18 (6.1%) View