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Rfam Downloads • Latest release:

Covariance models, seed alignments, genome annotations, sequences, and more — all freely available under the Creative Commons Zero (CC0) licence

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Browse: ftp.ebi.ac.uk/pub/databases/Rfam/

CURRENT/ always points to the latest release. Older releases live in versioned directories (e.g. 15.0/, 14.10/).

Need help with file formats and directory structure? See the FTP documentation.

Current release files

Rfam.cm.gz

Covariance models

All Rfam covariance models in a single file, suitable for use with Infernal's cmscan to annotate novel sequences.

Rfam.seed.gz

Seed alignments

Multiple sequence alignments for all families in Stockholm format, including consensus secondary structures.

Rfam.full_region.gz

Full region hits

All genome hits for every Rfam family: sequence accession, coordinates, strand, score, and E-value.

fasta_files/

FASTA sequences

Per-family FASTA files containing all sequences used to build each covariance model.

Rfam.clanin

Clan membership

Clan definitions listing which families belong to each clan, for use with Infernal's cmscan --clanin.

This page lists the most commonly used files. Many more are available in the release directory. See all current files →

Release history

Release Date Families Status FTP Directory
Browse all releases on FTP →