{"rfam": {"acc": "RF03125", "id": "Sarbecovirus-3UTR", "description": "Sarbecovirus 3'UTR", "comment": "The Sarbecovirus 3'UTR is similar to other betacoronaviruses and is approximately 300-500 nucleotides long. The most 5' structure is the bulged stem-loop (BSL), starting downstream of the N gene stop codon and is essential for viral replication. It is predicted to be conserved among betacoronaviruses. Downstream to the BSL lies the hypervariable bulged-stem loop region (HVR), containing a triple helix junction. The hairpin stem from this junction participates in the pseudoknot pairing with the BSL region. The pseudoknot and the BSL partially overlap and therefore cannot be formed at the same time. It is proposed that the BSL and pseudoknot act as a molecular switch that may regulate a transition during viral RNA synthesis. Part of the HVR is the octanucleotide sequence '5-GGAAGAGC-3' which is conserved among alpha- and betacoronaviruses.", "curation": {"author": "Lamkiewicz K", "seed_source": "Lamkiewicz K", "num_seed": 11, "num_full": 7, "num_species": 15, "type": "Cis-reg;", "structure_source": "Predicted;"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 30.00 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 179.7, "trusted": 179.8, "noise": 133.0}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": "CL00117", "id": "Coronavirus-3UTR"}}}