{"rfam": {"acc": "RF03117", "id": "bCoV-5UTR", "description": "Betacoronavirus 5'UTR", "comment": "The first 150 to 200 nucleotides within the 5' UTR of betacoronaviruses are highly structured and shown to be conserved on a structure level among betacoronaviruses. It has been predicted to contain 3 conserved stem-loops (SL1, SL2 and SL4). SARS-CoV and BCoV have an additional stem-loop, called SL3, which contains the TRS-L sequence in its loop region. However, according to predictions, SL3 is not stable in other betacoronaviruses like MHV. SL1 is important for viral replication, most likely playing a role in the template-switch of viral subgenomic RNA transcription. SL2 is crucial for viral viability, however, the nucleotide sequence can be mutated and some residues, as long as the structure remains stable. SL4 is hypothesized to play a role in directing subgenomic RNA synthesis during viral replication.", "curation": {"author": "Lamkiewicz K", "seed_source": "Lamkiewicz K", "num_seed": 17, "num_full": 18, "num_species": 25, "type": "Cis-reg;", "structure_source": "Predicted;"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 30.00 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 111.6, "trusted": 125.5, "noise": 110.3}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": "CL00116", "id": "Coronavirus-5UTR"}}}