{"rfam": {"acc": "RF00616", "id": "LhrC", "description": "Listeria LhrC", "comment": "This RNA was identifed by screening for RNA molecules which co-immunoprecipitated with the RNA chaperone Hfq [1]. However, neither the stability nor the activity of LhrC is depending on the presence of Hfq[2][3]. LhrC is transcribed from the intergenic region between the protein coding genes cysK, a putative cysteine synthase and sul, a putative dihydropteroate synthase [1]. In Listeria monocytogenes four additional copies of lhrC have been identifed in the genome, three of which are located in tandem repeat upstream of the originally characterised lhrC [1]. This RNA molecule appears to be conserved amongst Listeria species but has not been identified in other bacterial species. The direct mRNA targets of LhrC are the virulence adhesion LapB, and the oligo-peptide binding protein OppA. The 3 conserved UCCC motifs common to all copies of LhrC are involved in the mRNA binding and post-transcriptional repression of the target genes. Interestingly, 2 other Listerina monocytogenes sRNAs Rli22 and Rli33 contain two UCCC motifs and use them to repress oppA mRNA expression.[4]", "curation": {"author": "Daub J", "seed_source": "Daub J", "num_seed": 12, "num_full": 13, "num_species": 12, "type": "Gene; sRNA;", "structure_source": "Published; PMID:16682563"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 34.69 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 110.0, "trusted": 110.3, "noise": 108.4}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": "CL00114", "id": "LhrC"}}}