{"rfam": {"acc": "RF00460", "id": "U1A_PIE", "description": "U1A polyadenylation inhibition element (PIE)", "comment": "This family represents the U1A polyadenylation inhibition element (PIE). PIE is a regulatory RNA which is responsible for the regulation of the length of the polyA tail of the U1A pre-mRNA. The PIE is located in the U1A mRNA 3' UTR. PIE adopts a U-shaped structure, with binding sites for a single U1A protein at each bend and when complexed with the two proteins it blocks activity of poly(A) polymerase (PAP), and inhibits its activity [1,2].", "curation": {"author": "Moxon SJ, Weinberg Z", "seed_source": "PMID:15491147", "num_seed": 39, "num_full": 510, "num_species": 331, "type": "Cis-reg;", "structure_source": "Published; PMID:15491147"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 27.06 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 50.0, "trusted": 50.0, "noise": 49.8}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": null, "id": null}}}