{"rfam": {"acc": "RF00449", "id": "IRES_HIF1", "description": "HIF-1 alpha IRES", "comment": "This family represents the hypoxia-inducible factor 1-alpha internal ribosome entry site. HIF-1a is a subunit of the HIF-1 transcription factor, which induces transcription of several genes involved in the cellular response to hypoxia. The HIF-1a IRES allows translation to be maintained under hypoxic cell conditions that inhibit cap-dependent translation [1].", "curation": {"author": "Moxon SJ", "seed_source": "http://ifr31w3.toulouse.inserm.fr/IRESdatabase/, INFERNAL", "num_seed": 17, "num_full": 112, "num_species": 114, "type": "Cis-reg; IRES;", "structure_source": "Predicted; RNAFOLD; Moxon SJ"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 17.00 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 110.0, "trusted": 134.0, "noise": 106.7}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": null, "id": null}}}