# STOCKHOLM 1.0
#=GF ID GAIT
#=GF AC RF00179
#=GF DE GAIT element
#=GF AU Moxon SJ; 0000-0003-4644-1816
#=GF GA 37.0
#=GF NC 36.7
#=GF TC 37.1
#=GF SE See reference [1]
#=GF SS Published; PMID:12588972
#=GF TP Cis-reg;
#=GF BM cmbuild -F CM SEED
#=GF CB cmcalibrate --mpi CM
#=GF SM cmsearch --cpu 4 --verbose --nohmmonly -T 29.23 -Z 2958934 CM SEQDB
#=GF DR GO; 0017148; negative regulation of translation;
#=GF DR SO; 0000655; ncRNA;
#=GF RN [1]
#=GF RM 12588972
#=GF RT Transcript-selective translational silencing by gamma interferon is
#=GF RT directed by a novel structural element in the ceruloplasmin mRNA 3'
#=GF RT untranslated region.
#=GF RA Sampath P, Mazumder B, Seshadri V, Fox PL
#=GF RL Mol Cell Biol 2003;23:1509-1519.
#=GF CC This family represents a cis-acting element in the 3'-UTR of the
#=GF CC ceruloplasmin (Cp) gene called gamma interferon inhibitor of translation
#=GF CC (GAIT). The GAIT element is involved in selective translational silencing
#=GF CC of the Cp transcript. Ceruloplasmin (Cp) is a multifunctional,
#=GF CC copper-containing glycoprotein produced by the liver and secreted into the
#=GF CC plasma. As an acute-phase protein, its plasma concentration can double
#=GF CC during multiple inflammatory conditions. Plasma Cp has been reported to be
#=GF CC an independent risk factor for cardiovascular disease, including
#=GF CC atherosclerosis, carotid restenosis after endarterectomy, and myocardial
#=GF CC infarction. Translational silencing of Cp, and possibly other transcripts,
#=GF CC mediated by the GAIT element may contribute to the resolution of the local
#=GF CC inflammatory response following cytokine activation of macrophages [1].
#=GF WK GAIT_element
#=GF SQ 8

AC131209.2/6785-6855   GUAUGUGAAAGUGUAAAAUAGAAUGUUACUUUGGAAUGACUAUAAACAUUAAAAGAAGACUGGAAGCAUAC
AC104966.4/51221-51291 GUAUGUGAAAGUGUAAAAUAGAAUGUUACUUUGGAAUGACUAUAAACAUUGAAAGAAGACUGGAAACAUAC
AK095290.1/2797-2865   GUAUGUGAAAGUGUAAAAUAGAAUGUUACUUUGGAAUGACUAUAAACAUUAAAAGAAGACUGGAAGCAU--
M13699.1/3255-3321     GUAUGUGAAAGUGUAAAAUAGAAUGUUACUUUGGAAUGACUAUAAACAUUAAAAGA-GACUGGA-GCAU--
D45045.2/8585-8655     GUAUGUGAAAGUGUAAAAUAGAAUGUUACUUUGGAAUGACUAUAAACAUUAAAAGAAGACUGGAAGCAUAC
M18058.1/1580-1650     GUAUGUGAAAGUGUAAAAUAGAAUGUUACUUUGGAAUGACUAUAAACAUUGAAAGAAGACUGGAAACAUAC
X69706.1/260-330       GUAUGUGAAAGUGUAAAAUAGAAUGUUACUUUGGAAUGACUAUAAACAUUAAAAGAAGACUGGAAGCAUAC
M13536.1/2617-2687     GUAUGUGAAAGUGUAAAAUAGAAUGUUACUUUGGAAUGACUAUAAACAUUAAAAGAAGACUGGAAGCAUAC
#=GC SS_cons           <<<<<<---<<<---------<<<<<<----<<<_____>>>-->>>>>>-------->>>---->>>>>>
#=GC RF                GuaUGuGAAaGUGUAAAAUAGaaUGUUACUUUgGAAUGACuAUAAACAuuAAAAGAAGACuGGAAgCAuaC
//
