# STOCKHOLM 1.0 #=GF ID Purine #=GF AC RF00167 #=GF DE Purine riboswitch aptamer #=GF AU Breaker RR; 0000-0002-2165-536X #=GF GA 37.0 #=GF NC 36.9 #=GF TC 37.0 #=GF SE Boese B, Barrick JE #=GF SS Published; PMID:12787499 #=GF TP Cis-reg; riboswitch; #=GF BM cmbuild -F CM SEED #=GF CB cmcalibrate --mpi CM #=GF SM cmsearch --cpu 4 --verbose --nohmmonly -T 30.00 -Z 2958934 CM SEQDB #=GF CL CL00123 #=GF DR SO; 0000035; riboswitch; #=GF DR GO; 0009113; purine nucleobase biosynthetic process; #=GF RN [1] #=GF RM 12787499 #=GF RT Riboswitches Control Fundamental Biochemical Pathways in Bacillus subtilis #=GF RT and Other Bacteria. #=GF RA Mandal M, Boese B, Barrick JE, Winkler WC, Breaker RR #=GF RL Cell 2003;113:577-586. #=GF RN [2] #=GF RM 14718920 #=GF RT Adenine riboswitches and gene activation by disruption of a transcription #=GF RT terminator. #=GF RA Mandal M, Breaker RR #=GF RL Nat Struct Mol Biol 2004;11:29-35. #=GF RN [3] #=GF RM 15549109 #=GF RT Structure of a natural guanine-responsive riboswitch complexed with the #=GF RT metabolite hypoxanthine. #=GF RA Batey RT, Gilbert SD, Montange RK #=GF RL Nature. 2004;432:411-415. #=GF RN [4] #=GF RM 23842498 #=GF RT Three-state mechanism couples ligand and temperature sensing in #=GF RT riboswitches. #=GF RA Reining A, Nozinovic S, Schlepckow K, Buhr F, Furtig B, Schwalbe H #=GF RL Nature. 2013;499:355-359. #=GF CC Riboswitches are metabolite binding domains within certain messenger RNAs #=GF CC that serve as precision sensors for their corresponding targets. #=GF CC Allosteric rearrangement of mRNA structure is mediated by ligand binding, #=GF CC and this results in modulation of gene expression. A class of riboswitches #=GF CC that selectively recognises guanine and becomes saturated at #=GF CC concentrations as low as 5 nM. In Bacillus subtilis, this mRNA motif is #=GF CC located on at least five separate transcriptional units that together #=GF CC encode 17 genes that are mostly involved in purine transport and purine #=GF CC nucleotide biosynthesis. It has also been shown that some members of this #=GF CC family are specific for adenine instead. 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