# STOCKHOLM 1.0
#=GF ID let-7
#=GF AC RF00027
#=GF DE let-7 microRNA precursor family
#=GF AU Ontiveros-Palacios N; 0000-0001-8457-4455
#=GF GA 53.5
#=GF NC 53.4
#=GF TC 53.5
#=GF SE Griffiths-Jones SR
#=GF SS Predicted; RNAalifold
#=GF TP Gene; miRNA;
#=GF BM cmbuild -F CM SEED
#=GF CB cmcalibrate --mpi CM
#=GF SM cmsearch --cpu 4 --verbose --nohmmonly -T 30.00 -Z 2958934 CM SEQDB
#=GF CL CL00148
#=GF DR MIPF; MIPF0000002;
#=GF DR SO; 0001244; pre_miRNA;
#=GF DR GO; 0035195; miRNA-mediated post-transcriptional gene silencing;
#=GF DR GO; 0016442; RISC complex;
#=GF RN [1]
#=GF RM 11533718
#=GF RT Control of developmental timing in animals.
#=GF RA Rougvie AE
#=GF RL Nat Rev Genet 2001;2:690-701.
#=GF RN [2]
#=GF RM 11779458
#=GF RT microRNAs: tiny regulators with great potential.
#=GF RA Ambros V
#=GF RL Cell 2001;107:823-826.
#=GF RN [3]
#=GF RM 29706542
#=GF RT Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA
#=GF RT Substrate.
#=GF RA Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang QC, Wang HW
#=GF RL Cell. 2018;173:1191-1203.
#=GF RN [4]
#=GF RM 30423142
#=GF RT miRBase: from microRNA sequences to function.
#=GF RA Kozomara A, Birgaoanu M, Griffiths-Jones S
#=GF RL Nucleic Acids Res. 2019;47:D155.
#=GF CC This family represents the microRNAs (miRNA) let-7 and mir-98. let-7 was
#=GF CC identified from a study of developmental timing in C. elegans [1], and was
#=GF CC later shown to be part of a much larger class of non-coding RNAs termed
#=GF CC miRNAs [2]. Both miRNAs let-7 and mir-98 have now been predicted or
#=GF CC experimentally confirmed in a wide range of species (MIPF:MIPF000002).
#=GF CC miRNAs are transcribed as ~70nt precursors (modelled here) and
#=GF CC subsequently processed by the Dicer enzyme to give a ~22nt product. The
#=GF CC extents of the hairpin precursors are not generally known and are
#=GF CC estimated based on hairpin prediction. The products are thought to have
#=GF CC regulatory roles through complementarity to mRNA. The involvement of Dicer
#=GF CC in miRNA processing suggests a relationship with the phenomenon of RNA
#=GF CC interference. This family also includes the miR-98 precursor from human,
#=GF CC which may be a let-7 homologue. The pre-miRNA structure of let-7 has been
#=GF CC reported in complex with Dicer-TRBP [3]. Family represents miRNA precursor
#=GF CC let-7 imported from miRBase [4].
#=GF WK let-7_microRNA_precursor
#=GF SQ 64

Z70203.2/12451-12379                          UCCGGU-GAGGUAGUAGGUUGUA-UAGUU----UGG------AAUAUUA--CCA-----CCGGUG--AACUAUGCAAUUUUCUACCUU-ACCGGA
URS0000052456_9606/1-87                       CCUGGCUGAGGUAGUAGUUUGUG-CUGUUGGUCGGGUU---GUGACAUU-GCCC--GCUGUGGAGAUAACUGCGCAAGCUACUGCCUU-GCUAGU
AC018755.3/119936-120011                      CCGGGCUGAGGUAGGAGGUUGUA-UAGUU----GAGG------AGGACA-CC-C-----AAGGAGAUCACUAUACGGCCUCCUAGCUU-UCCCCA
AL049853.1/18009-17931                        UUGGGGUGAGGUAGUAGGUUGUA-UAGUUUG--GGGC---------UCU-GCCC--UGCUAUGGGAUAACUAUACAAUCUACUGUCUU-UCCUGA
AP000962.2/118093-118168                      CCGGGUUGAGGUAGUAGGUUGUA-UGGUUU--AGAGU---------UAC-ACCC-----UGGGAGUUAACUGUACAACCUUCUAGCUU-UCCUUG
AF210771.1/1883-1955                          UACGGU-GAGGUAGUAGGUUGUA-UAGUUU--AGAAU---------AUU-ACUC-----UCGGUG--AACUAUGCAAGUUUCUACCUC-ACCGAA
AL158152.18/38291-38377                       UCAGAGUGAGGUAGUAGAUUGUA-UAGUUGU-GGGGUA---GUGAUUUU-ACCC-UGUUCAGGAGAUAACUAUACAAUCUAUUGCCUU-CCCUGA
AL158152.18/40779-40863                       CUAGGAAGAGGUAGUAGGUUGCA-UAGUUUU-AGGGCA---GGGAUUUU-GCCC---ACAAGGAGGUAACUAUACGACCUGCUGCCUU-UCUUAG
AL158152.18/37901-37981                       -UGGGAUGAGGUAGUAGGUUGUA-UAGUUUU-AGGGU---------CAC-ACCCACCACUGGGAGAUAACUAUACAAUCUACUGUCUU-UCCUAA
AC094021.2/47340-47253                        CCAGGCUGAGGUAGUAGUUUGUA-CAGUUUG-AGGGUC--UAUGAUACC-ACCC-GGUACAGGAGAUAACUGUACAGGCCACUGCCUU-GCCAGG
AP001359.4/114553-114478                      CCAGGUUGAGGUAGUAGGUUGUA-UAGUUU--AGA----------AUUA-CAUC----AAGGGAGAUAACUGUACAGCCUCCUAGCUU-UCCUUG
AF480570.1/1-79                               -----GUGAGGUAGUAAGUUGUA-UUGUUGU-GGGGUAGGGAUAUUAGG-CCCC--AAUUAGAAGAUAACUAUACAACUUACUACUUU-C-----
BX005154.6/63678-63599                        GCAGGCUGAGGUAGUUGGUUGUA-UGGUUUU-GCAUC-----AUAAUCA-GCCU-------GGAGUUAACUGUACAACCUUCUAGCUUUCCCUGC
AY866046.1/496-584                            CCAGGGUGAGGUAGUAAGUUGUA-UUGUUGU-GGGGUAG-GGAUAUUAG-GCCC-CAAUUAGAAGAUAACUAUACAACUUACUACUUU-CCCUGG
URS000070A416_10090/2-79                      UUGGGGUGAGGUAGUAGGUUGUA-UGGUUUU--GGGC---------UCU-GCCC--CGCUCUGCGGUAACUAUACAAUCUACUGUCUU-UCCUGA
AAVX01008163.1/128-212                        CUGGGUAGAGGUAGUAGGUUGCA-UAGUUUG-AGGGCA---GGGAUUUU-GCCC---CAAAGGAGAUAACUAUACAACCUGCUGCCUU-UCCUGG
BAAE01218263.1/598-683                        ACAGGGUGAGGUAGUAGGUUGUG-UGGUUUC-AGGGUU---GUGAUUUU-ACCC--CAUAAGGAGCUAACUAUACAACCUACUGCCUU-CCCUGG
CAAE01014991.1/464883-464800                  UCAGGGUGAGGUAGUAGGUUGUA-UAGUUUG-GUGGG-----UGGGAUU-GCCC--ACUCAGGUGAUAACUAUACAGUCUAUUGCCUU-CCCUGA
AANG01619101.1/1216-1136                      GUGGGAUGAGGUAGUAGAUUGUA-UAGUUUU-AGGGU--------CAUA-CCCC--AUCUUGGAGAUAACUAUACAGUCUACUGUCUU-UCCCAC
AANH01007764.1/36699-36614                    ACAGGGUGAGGUAGUAGGUUGUG-UGGUUUC-AGGGUU---GUUAUUUU-ACCC--CAUCGGGAGUUAACUAUACAACCUACUGCCUU-UCCUGG
AAYZ01324012.1/2457-2541                      ACGGGGUGAGGUAGUAGGUUGUG-UGGUUUC-AGGGCG---GUGAUGUC-GCCC---CUCAGCAGAUAACUAUACAGCCUACUGCCUU-CCCUGA
AAFR03057393.1/4201-4115                      GCGGGGUGAGGUAGUAGGUUGUG-UGGUUUC-AGGGUA---GUGAUUUU-GCCC-CAAUCAGAAGAUAACUAUACAACCUACUGCCUU-CCCUGA
AAPY01378069.1/2181-2093                      CUGGGGUGAGGUAGUAAGUUGUA-UUGUUGU-GGGGUUGGGAUUGUAGA-CCCC--AAUUAGAAGAUAACUAUACAACUUACUACUUU-CCCUGG
AAPN01341034.1/3404-3318                      GCGGGAUGAGGUAGUAGGUUGUG-UGGUUUC-AGGGGA---GUGAUUUUGCCCC--AAUCAGAAGAUAACUAUACAGCCUACUGCCUU-CCCUGG
AAIY01003579.1/1841-1762                      GUAGGAUGAGGUAGUAGAUUGUA-UAGUUGU-AGGUC---------AUA-ACCC--AUCUUGGAGAUAACUAUACAGUCUACUGUCUU-UCCCAC
AANN01347783.1/1229-1152                      UUGGGGUGAGGUAGUAGGUUGUA-UAGUUUG--GGGC---------CCU-GCCC--UGCUAUGGGU-AACUAUACAAUCUACUGUCUU-UCCUGA
AAZX01015868.1/1070-988                       CCUGGGUGAGGUAGUAGGUUGUA-UAGUGGG-GAAUG------AAAAUU-CGUC--AUUAUGGAAUCCACUGUACAACUUGCUAACUU-UCCCGG
AALT01443655.1/3068-3143                      CCAGGUUGAGGUAGUGGGUUGUA-UAGUUCA-G---------AAUCACA-------UCAAGGGAGAUAACUGUACAGCCUCCUAGCUU-GCCUUG
AANU01169061.1/33054-33138                    CUAGGAAGAGGCAGCACGUUGCA-UAGUUCU-AGGGA----AGGCACUU-UUCC--CACUUGGGGGUAACUGUAUGCCCUGCUGCCUG-UCUUAG
AABS01000138.1/96907-96982                    GCAAGUUGAGGUAGUAGGUUAUAUCAGUUGA-U---------UAUAUGA--------ACCAGGAGAUAACUGUAUAGCCCACUAGCUU-ACUUGC
AAGD02006482.1/22892-22821                    UCUGGU-GAGGUAGUAGGUUGUA-UAGUU----UAGA-----------A-UCUU--ACCUUGGUG--AACUAUGCAAGUUUCUACCUC-ACCAGA
AACT01004141.1/13602-13519                    AUAACAUGAGGUAGUAGGUUAUG-CAGUUUG-GCGAC----AAUAUUUC-GUUG---CAAAGGAGAUAACUGUGUAACUUGCUGGCUC-UUUUAU
AAZO01005184.1/23361-23435                    CAGGGU-GAGGUAGUAGACUGUA-UAGUA----AAGA---------AUU-ACAU--CAUUUGGAGG-UACUGUACAAUCUGCUAACUU-UCCCUG
AANI01016295.1/2335-2404                      GCAAAUUGAGGUAGUAGGUUGUA-UAGUAGU-A-------------UUU----------AUAGAGCAUACUAUACAGCGUGCUAGCUUUCUUUGC
AAPT01004257.1/151-220                        GCAAAUUGAGGUAGUAGGUUGUA-UAGUAGU-A-----------------------UCUAUCUAGCAUACUAUACAGCUUGCUAGCUUUCUUUGC
AAQA01000457.1/25368-25290                    GCUCGAUGAGGUAGUAGGUUGUA-UAGUU----AUGA------GUUGUA-CCAU---AAUCGGAGA-AACUGUCCAGCCUGCUAGCUUGCCGUGC
AAJJ01000960.1/12168-12093                    UCUGUUUGAGGUAGUAGGUUGUA-UAGUA----AGUA---------UUA-CACC--UAUUGGGAG--UGCUGUACAGCCUGCUAACUUUCCCAGA
AAPP01015675.1/360249-360318                  GCAAAUUGAGGUAGUAGGUUGUA-UAGUAGC-A-----------------------ACUAAGAAUCGUACUAUACAAUGUGCUAGCUUUCUUUGC
AAPU01010514.1/89793-89724                    GCAAAUUGAGGUAGUAGGUUGUA-UAGUAGU-A-----------------------CUUAUAGACCAUACUAUACAGCGUGCUAGCUUUCUUUGC
AABU01002759.1/2931025-2930956                GCAAAUUGAGGUAGUAGGUUGUA-UAGUA----GUAA-------------UUAC--ACAUCA-----UACUAUACAAUGUGCUAGCUUUCUUUGC
AAQB01006449.1/358437-358507                  GCAAAUUGAGGUAGUAGGUUGUA-UAGUAGU-A---------------A-------UUAUUCAAUCAUACUAUACAAUGUGCUAGCUUUCUUUGC
AAFS01000369.1/71461-71393                    GCAAAUUGAGGUAGUAGGUUGUA-UAGUAGU-A------------------------CUUCAGAUCGUACUAUACAAUGUGCUAGCUUUCUUUGC
ACBE01248169.1/7760-7844                      CGGGGU-GAGGUAGUAGGUUGUG-UGGUUUC-AGGGCA---GUGAUGUU-GCCC--CCUCGGAAGAUAACUAUACAACCUACUGCCUU-CCCCGA
AAKN02054092.1/95811-95899                    CUGGGGUGAGGUAGUAAGUUGUA-UUGUUGU-GGGGUAAGGAUUUAAGG-CCCC--AUUAAGAAGAUAACUAUACGACUUACUACUUU-CCCUGG
AAGW02075197.1/23048-23132                    UCGGGGUGAGGUAGUAGGUUGUG-UGGUUUC-AGGGCA---GCGGUGUC-GCCC---CUCAGCAGAUAACUAUACAGCCUACUGCCUU-CCCCGA
AABR05153093.1/1773-1848                      CCAGGCUGAGGUAGUAGGUUGUA-UAGUUUA-G---------AGUUACA-------ACAAGGGAGAUAACUGUACAGCCUCCUAGCUU-UCCUUG
CAAE01013731.1/39581-39496                    ACGGGGUGAGGUAGUAGGUUGUG-UGGUUUC-AGGGUG---GUGAUAUU-GCCC--AAUCAGGAGAUAACUAUACAACCUACUGCCUU-CCCUGG
AY866050.1/490-568                            UUGGGGUGAGGUAGUAGGUUGUA-UAGUUU--GGGGC---------UCU-GCCC--UGCUAUGGGAUAACUAUACAAUCUACUGUCUU-UCCUGA
AY866357.1/820-906                            UCAGAGUGAGGUAGUAGAUUGUA-UAGUUGU-GGGGUA---GUGAUUUU-ACCC-UGUUCAGGAGAUAACUAUACAAUCUAUUGCCUU-CCCUGA
AF274345.1/1758-1830                          UCCGGU-GAGGUAGUAGGUUGUA-UAGUU----UGGA-------AUAUU-ACCA-----CCGGUG--AACUAUGCAAUUUUCUACCUU-ACCGGA
AY866017.1/450-525                            CCAGGUUGAGGUAGUAGGUUGUA-UAGUUUA-G---------AAUUACA-------UCAAGGGAGAUAACUGUACAGCCUCCUAGCUU-UCCUUG
AY866355.1/408-489                            GUGGGAUGAGGUAGUAGGUUGUA-UAGUUUU-AGGGU---------CAC-ACCCACCACUGGGAGAUAACUAUACAAUCUACUGUCUU-UCCUAA
AC231658.3/113295-113375                      GUGGGAUGAGGUAGUAGAUUGUA-UAGUUUU-AGGGU--------CAUA-CCCC--AUCUUGGAGAUAACUAUACAGUCUACUGUCUU-UCCCAC
AY866150.1/447-522                            CCGGGUUGAGGUAGUAGGUUGUA-UGGUUUA-G---------AGUUACA-------CCCUGGGAGUUAACUGUACAACCUUCUAGCUU-UCCUUG
AY866290.1/298-385                            CCAGGCUGAGGUAGUAGUUUGUA-CAGUUUG-AGGGUC--UAUGAUACC-ACCC-GGUACAGGAGAUAACUGUACAGGCCACUGCCUU-GCCAGG
EU624487.1/1401-1470                          GCAAAUUGAGGUAGUAGGUUGUA-UAGUAGU-A---A-------------U-------UACACAUCAUACUAUACAAUGUGCUAGCUUUCUUUGC
HM625839.1/191-271                            UUGGGGUGAGGUAGUAGGUUGUA-UAGUUUG-AGGGU---------UUA-ACCC-UUGCUGUCAGAUAACUAUACAACUUACUGUCUU-UCCCGA
AY866352.1/767-853                            UCAGAGUGAGGUAGUAGAUUGUA-UAGUUGU-GGGGUA---GUGAUUUU-ACCC-UGUUUAGGAGAUAACUAUACAAUCUAUUGCCUU-CCCUGA
HM625839.1/1002-1087                          ACAGGGUGAGGUAGUAGGUUGUG-UGGUUUC-AGGGUU---GUAAUUUU-GCCC--CAUCAGGAGAUAACUAUACAACCUACUGCCUU-CCCUGA
AY866020.1/478-553                            CCAGGCUGAGGUAGUAGGUUGUA-UAGUUUA-G---------AAUUACA-------UCAAGGGAGAUAACUGUACAGCCUCCUAGCUU-UCCUUG
URS00007078D8_10090/1-85                      CUAGGAAGAGGUAGUAGGUUGCA-UAGUUUU-AGGGCA---GAGAUUUU-GCCC---ACAAGGAGUUAACUAUACGACCUGCUGCCUU-UCUUAG
AY866019.1/258-334                            CCAGGUUGAGGUAGUAGGUUGUA-UAGUUUA-G---------AAUUACA-------UCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCCUGG
AY866051.1/437-516                            UGGGGGUGAGGUAGUAGGUUGUA-UAGUUUG-GGGGC---------UCU-GCCC--UGCUAUGGGAUAACUAUACUAUCUACUGUCUU-UCCUGA
URS0000D56C46_9606/1-73                       ------UGAGGUAGUAGGUUGUA-UAGUUUU-AGGGU---------CAC-ACCCACCACUGGGAGAUAACUAUACAAUCUACUGUCUU-ACC---
#=GR URS0000D56C46_9606/1-73        5ZAL_C_SS .......((((((((((((((((.(((((((.((((.........................))))))))))))))))))))))))))).......
#=GR URS0000D56C46_9606/1-73        5ZAM_C_SS ......((((((((((((((.......................................................))))))))))))).).....
#=GC SS_cons                                  ((((((-((((((((((((((((.((((,,,.,<<<<....._______.>>>>..,<<____>>,,,)))))))))))))))))))).))))))
#=GC RF                                       ccaGGcUGAGguAGuAgguUGuA.uAGUUuu.agggc.....ugauuuu.gccc..acuuaGGagaUAACUaUaCAaccUaCUacCUU.gCCugg
//
