{"rfam": {"acc": "RF00014", "id": "DsrA", "description": "DsrA RNA", "comment": "DsrA RNA regulates both transcription, by overcoming transcriptional silencing by the nucleoid-associated H-NS protein, and translation, by promoting efficient translation of the stress sigma factor, RpoS. These two activities of DsrA can be separated by mutation: the first of three stem-loops of the 85 nucleotide RNA is necessary for RpoS translation but not for anti-H-NS action, while the second stem-loop is essential for antisilencing and less critical for RpoS translation. The third stem-loop, which behaves as a transcription terminator, can be substituted by the trp transcription terminator without loss of either DsrA function. The sequence of the first stem-loop of DsrA is complementary with the upstream leader portion of RpoS messenger RNA, suggesting that pairing of DsrA with the RpoS message might be important for translational regulation.", "curation": {"author": "Bateman A", "seed_source": "Bateman A", "num_seed": 5, "num_full": 39, "num_species": 44, "type": "Gene; sRNA;", "structure_source": "Published; PMID:9770508"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 29.42 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 60.0, "trusted": 60.1, "noise": 59.2}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": null, "id": null}}}