{"rfam": {"acc": "RF01412", "id": "BsrG", "description": "BsrG", "comment": "bsrE, bsrG and bsrH pair through intermolecular interactions with antisense sRNAs. They form type I toxin/antitoxin system that includes an mRNA encoding for a short, toxic peptide (bsrE, bsrG and bsrH) and an antitoxin that is comprised of an antisense RNA.[7] bsrG encodes a 39-amino-acid toxin, and the 180 nucleotide antisense sRNA called SR4 acts as the antitoxin (they overlap by 123 nucleotides). SR4 interaction with the 3'UTR of bsrG RNA promotes bsrG degradation and inhibits its translation.[2][4] BsrG interferes with cell envelope biosynthesis, causes membrane invaginations and delocalisation of the cell wall synthesis and initiates autolysis.[3] bsrE RNA encodes 30 amino-acid toxin peptide. Its antitoxin gene, SR5 overlaps by 112 nucleotides at the 3' end of bsrE.[5] SR5 also overlaps bsrG from nucleotide 163 to 52 (Rfam overlap check). The antitoxin SR5 promotes bsrE degradation but unlike SR4 it does not directly inhibits toxin mRNA translation.[5][6]", "curation": {"author": "Gardner PP", "seed_source": "Predicted; WAR; Infernal", "num_seed": 6, "num_full": 614, "num_species": 343, "type": "Gene; sRNA;", "structure_source": "Predicted; WAR"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 23.34 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 55.0, "trusted": 55.0, "noise": 54.9}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": null, "id": null}}}