{"rfam": {"acc": "RF00621", "id": "CoTC_ribozyme", "description": "Beta-globin co-transcriptional cleavage ribozyme", "comment": "Transcription termination of RNA polymerase II transcripts is proposed to occur by a two stage process [1]. The first stage involves pre-termination cleavage (PTC) of the nascent transcript downstream of the poly(A) site. This process is also referred to as co-transcriptional cleavage (CoTC). The CoTC process in the human beta-globin gene has been shown to involve an RNA self-cleaving activity located in the 3' flanking region of the beta-globin gene. This Rfam model represents the catalytic core of the beta-globin CoTC ribozyme. The CoTC core is highly conserved in the 3' flanking regions of other primate beta-globin genes [2]. Functionally, this CoTC ribozyme resembles the 3' processive, self-cleaving ribozymes described for the protein-encoding genes from the myxomycetes Didymium iridis and Physarum polycephalum [2].", "curation": {"author": "Daub J", "seed_source": "Daub J", "num_seed": 10, "num_full": 76, "num_species": 74, "type": "Gene; ribozyme;", "structure_source": "Published; PMID:15565159"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 28.72 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 58.0, "trusted": 58.8, "noise": 57.4}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": null, "id": null}}}