{"rfam": {"acc": "RF00581", "id": "SNORD12", "description": "Small nucleolar SNORD12/SNORD106", "comment": "This family belong to the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. This family includes the human ortholog of mouse snoRNA HBII-99 and human snoRNA U106. In humans both HB11-99 and U106 snoRNAs share the same host gene [1]. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. HBII-99 is predicted to guide the 2'O-ribose methylation of 28S rRNA G3878 [2]. U106 contains conserved antisense elements which would predict U106 methylates residues G1536 and U1602 of 18S rRNA. However, these targets do not appear to be methylated and U106 might function as an RNA chaperone during rRNA folding [1]. A similar role has been suggested for the H/ACA snoRNAs U17a and U17b Rfam:RF00045 [1].", "curation": {"author": "Marantidis E, Daub J", "seed_source": "Marantidis E.", "num_seed": 8, "num_full": 2264, "num_species": 650, "type": "Gene; snRNA; snoRNA; CD-box;", "structure_source": "Predicted; RNAalifold, Daub J"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 27.91 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 43.0, "trusted": 43.2, "noise": 42.9}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": "CL00044", "id": "SNORD12"}}}