{"rfam": {"acc": "RF00435", "id": "ROSE", "description": "Repression of heat shock gene expression (ROSE) element", "comment": "This family represents a 5' UTR cis-regulatory element found in heat shock mRNAs and is known as the ROSE (repression of heat shock gene expression) element. The ROSE element is a negative regulator of heat shock gene expression. The secondary structure is thought to be regulated by temperature. This regulation blocks access to the ribosome binding site under normal conditions. During heat shock however, the structure changes freeing the ribosome binding site and allowing expression to occur [1,2].", "curation": {"author": "Moxon SJ, Bateman A", "seed_source": "PMID:11726689", "num_seed": 13, "num_full": 381, "num_species": 262, "type": "Cis-reg; thermoregulator;", "structure_source": "Published; PMID:11726689; Griffiths-Jones S"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 30.00 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 45.0, "trusted": 45.2, "noise": 44.9}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": null, "id": null}}}