{"rfam": {"acc": "RF00283", "id": "SCARNA18", "description": "small Cajal body-specific RNA 18", "comment": "scaRNAs are a specific class of small nuclear RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12 [1]. This C/D box domain U91 (also known as U4-8) was identified by Darzacq and is predicted to guide the 2'O-ribose methylation of U4 snRNA C8 [1]. This C/D domain was later found associated in tandem with another C/D box domain U12-22 (RFAM:RF00492). Both the doublet (U12-22/U4-8) and singlet (U4-8) forms of this snRNA have been purified from Hela cells [1]. The doublet form U12-22/U4-8 has been shown to localise to the nucleoplasm and is proposed to reside in the Cajal bodies whereas the U4-8 single domain appears to accumulate in the nucleolus [3]. In humans the genomic location of U12-88/U4-8 is intergenic and the purified transcript has been shown to possess a methylated guanosine cap suggesting it is independently transcribed by RNA pol II [3].", "curation": {"author": "Moxon SJ, Daub J", "seed_source": "PMID:12032087, INFERNAL", "num_seed": 20, "num_full": 406, "num_species": 191, "type": "Gene; snRNA; snoRNA; scaRNA;", "structure_source": "Predicted; PFOLD; Moxon SJ"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 25.63 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 40.0, "trusted": 40.1, "noise": 39.9}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": null, "id": null}}}