{"rfam": {"acc": "RF00254", "id": "mir-16", "description": "mir-16 microRNA precursor family", "comment": "miR-16, miR-15, mir-195 and miR-457 are related miRNA precursor sequences (MIPF:MIPF000006). This miRNA family appears to be vertebrate specific and members of this family have been predicted or experimentally validated in a wide range of vertebrate species (MIPF:MIPF0000006). miR-16 and miR-15a are clustered within 0.5 kb at 13q14 in human, a region shown to be deleted or down-regulated in more than half of B cell chronic lymphocytic leukaemias (CLL) [1]. The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation -- their extents are not known. In this case the mature sequence is excised from the 5' arm of the hairpin. The structure of mir-16 has been reported in PDB: 6LXD, 6V5B and 6V5C [2,3].", "curation": {"author": "Griffiths-Jones SR, Ontiveros-Palacios N, Daub J", "seed_source": "Griffiths-Jones SR", "num_seed": 14, "num_full": 4705, "num_species": 758, "type": "Gene; miRNA;", "structure_source": "Predicted; PFOLD"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 30.00 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 36.5, "trusted": 36.5, "noise": 36.4}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": "CL00085", "id": "mir-15"}}}