{"rfam": {"acc": "RF00183", "id": "G-CSF_SLDE", "description": "G-CSF factor stem-loop destabilising element (SLDE)", "comment": "This family represents the granulocyte colony-stimulating factor stem-loop destabilising element (G-CSF SLDE). G-CSF is secreted by fibroblasts and endothelial cells in response to the inflammatory mediators interleukin-1 (IL-1) and tumour necrosis factor alpha and by activated macrophages. The synthesis of G-CSF is regulated both transcriptionally and through control of mRNA stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and also in the case of monocytes and macrophages, in response to lipopolysaccharide. It is likely that the presence of the SLDE in the G-CSF mRNA contributes to the specificity of regulation of G-CSF mRNA and enhances the rate of shortening of the poly(A) tail [1].", "curation": {"author": "Moxon SJ", "seed_source": "PMID:11865046", "num_seed": 16, "num_full": 132, "num_species": 132, "type": "Cis-reg;", "structure_source": "Published; PMID:11865046"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 29.14 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 45.0, "trusted": 46.7, "noise": 41.8}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": null, "id": null}}}