{"rfam": {"acc": "RF00180", "id": "REN-SRE", "description": "Renin stability regulatory element (REN-SRE)", "comment": "This family represents a cis-acting element in the 3'-UTR of the renin (REN) gene called renin stability regulatory element (REN-SRE) which acts to regulate renin production. REN-SRE is thought to destabilise the mRNA, promoting degradation of the sequence. It has been found that a number of proteins bind to the REN-SRE to stabilise the mRNA and promote translation. Renin is secreted by renal juxtaglomerular cells and catalyses the conversion of angiotensinogen into angiotensin I which is the rate-limiting step in the production of angiotensin II. Angiotensin II induces hypertension and REN therefore requires tight control to ensure expression appropriate to need [1].", "curation": {"author": "Moxon SJ", "seed_source": "PMID:12933794", "num_seed": 13, "num_full": 120, "num_species": 115, "type": "Cis-reg;", "structure_source": "Published; PMID:12933794"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 23.67 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 41.0, "trusted": 41.0, "noise": 40.8}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": null, "id": null}}}