{"rfam": {"acc": "RF00121", "id": "MicC", "description": "MicC RNA", "comment": "MicC (previously known as IS063 [1]) is located between the ompN and ydbK genes in E. coli. This family of Hfq-associated sRNA is thought to be a regulator of OmpC expression. MicC inhibits the 30S ribosome binding through a conserved 22 bp RNA duplex near the start codon of the ompC mRNA. Along with Rfam:RF00033 it may act in conjunction with EnvZ-OmpR two-component system to control the OmpF/OmpC protein ratio in response to a variety of environmental stimuli [2]. The expression of micC was shown to be increased in the presence of beta-lactam antibiotics. The metabolic activity of E.coli expressing either OmpC or OmpF was strongly inhibited upon exposure to beta-lactams [3].", "curation": {"author": "Moxon SJ", "seed_source": "Hershberg R", "num_seed": 8, "num_full": 24, "num_species": 30, "type": "Gene; sRNA;", "structure_source": "Predicted; PFOLD"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 30.00 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 90.0, "trusted": 96.4, "noise": 71.8}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": null, "id": null}}}