{"rfam": {"acc": "RF00112", "id": "CyaR_RyeE", "description": "CyaR/Rye RNA", "comment": "This sRNA was originally identified in a large scale screen of E. coli. It was shown to bind Hfq and called RyeE [1]. This sRNA has since been characterised as a post-transcriptional regulator of the 18 kDa OmpX porin in Salmonella [2]. Phylogenetic and mutational analyses suggest that a conserved RNA hairpin of this sRNA which features a C-rich apical loop, acts to sequester the Shine-Dalgarno sequence of ompX mRNA and inhibits translational initiation [2]. The expression of this sRNA has been shown to be tightly controlled by the cyclic AMP receptor protein, CRP and has been renamed CyaR (cyclic AMP-activated RNA)[2]. CyaR appears to be highly conserved amongst enterobacteria and the cyaR gene is frequently located downstream of the yegQ gene.", "curation": {"author": "Bateman A, Daub J", "seed_source": "Gottesman S, Storz G, INFERNAL", "num_seed": 17, "num_full": 98, "num_species": 114, "type": "Gene; sRNA;", "structure_source": "Predicted; PFOLD"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 30.05 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 47.0, "trusted": 48.3, "noise": 46.7}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": null, "id": null}}}