{"rfam": {"acc": "RF00018", "id": "CsrB", "description": "CsrB/RsmB RNA family", "comment": "The CsrB RNA binds to approximately 18 copies of the CsrA protein Pfam:PF02599. CsrA proteins are found in a wide variety of bacteria. The CsrB RNAs contain a conserved motif CAGGXXG that is found in up to 18 copies and has been suggested to bind CsrA. The Csr regulatory system has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis [1]. In other bacteria such as Erwinia caratovara the RsmA protein has been shown to regulate the production of virulence determinants, such extracellular enzymes [2]. RsmA binds to RsmB regulatory RNA which is also a member of this family [2]. RsmB RNA was shown to be upregulated by GacS/A system, and increase downstream T3SS gene expression.[6] FlhDC, the master regulator of flagellar genes, also activates rsmB RNA production.[7] A regulatory network have been revealed connecting rsmB, FlhDC and T3SS.[8] Plays role in the biocontrol activity of Rahnella aquatilis HX2 (a biocontrol agent producing antibacterial substance).[5]", "curation": {"author": "Bateman A, Gardner PP", "seed_source": "Bateman A", "num_seed": 38, "num_full": 269, "num_species": 222, "type": "Gene; sRNA;", "structure_source": "Predicted; PFOLD; Bateman A; Gardner PP;"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 19.98 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 71.0, "trusted": 71.0, "noise": 70.9}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": "CL00106", "id": "Csr_Rsm_clan"}}}