{"rfam": {"acc": "RF00004", "id": "U2", "description": "U2 spliceosomal RNA", "comment": "U2 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Complementary binding between U2 snRNA (in an area lying towards the 5' end but 3' to hairpin I) and the branchpoint sequence (BPS) of the intron results the bulging out of an unpaired adenosine, on the BPS, which initiates a nucleophilic attack at the intronic 5' splice site, thus starting the first of two transesterification reactions that mediate splicing.", "curation": {"author": "Griffiths-Jones SR, Mifsud W, Gardner PP", "seed_source": "The uRNA database, PMID:9016512; Griffiths-Jones SR; PMID:18390578", "num_seed": 208, "num_full": 71512, "num_species": 2642, "type": "Gene; snRNA; splicing;", "structure_source": "Published; PMID:2339054; Griffiths-Jones SR"}, "cm": {"build_command": "cmbuild -F CM SEED", "calibrate_command": "cmcalibrate --mpi CM", "search_command": "cmsearch --cpu 4 --verbose --nohmmonly -T 27.09 -Z 2958934 CM SEQDB", "cutoffs": {"gathering": 46.0, "trusted": 46.0, "noise": 45.9}}, "release": {"date": "2026-01-16", "number": "15.1"}, "clan": {"acc": "CL00006", "id": "U2"}}}